Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-2-methyl-1-propanol → 4-tert-Butyl-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-2-methyl-1-propanol | HCID 11807 | — |
| 반응물 | 4-tert-Butylbenzoyl chloride | HCID 74372 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-tert-Butyl-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzamide | HCID 320076 | 105.5% |
반응 단계
30.95 g (347 mmol) of 2-amino-2-methyl-1-propanol was weighed into a 500 mL Erlenmeyer flask fitted with a stir bar and septum. Added 200 mL CH2Cl2. Established and maintained nitrogen atmosphere. Stirred the solution in an ice/water bath. Added 34 mL (174 mmol) of 4-tert-butylbenzoyl chloride dropwise over 30 min. A white precipitate formed. Stirred at room temperature overnight. Removed the solids by filtration and washed with CH2Cl2. Removed the solvent from the filtrate on rotavap and dried at 60°/4 torr to obtain 45.79 g of the title compound as a light yellow resin. MS (EST) 248 (M−H)−.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822457B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-159bc30cce2642eea6900f4e4030b699 |
| 출처 메모 | uspto-grants-2014_09 |