Allylamine → N-allyl-5-chlorothiophenecarboxamide
반응식
[CH2:1]([NH2:4])[CH:2]=[CH2:3].[Cl:5][C:6]1[S:10][C:9]([C:11](Cl)=[O:12])=[CH:8][CH:7]=1>N1C=CC=CC=1.C1COCC1>[CH2:1]([NH:4][C:11]([C:9]1[S:10][C:6]([Cl:5])=[CH:7][CH:8]=1)=[O:12])[CH:2]=[CH2:3]참가 물질
5
실험 절차
An ice-cooled solution of 2.63 ml (35 mmol) of allylamine in 14.2 ml of absolute pyridine and 14.2 ml of absolute THF is admixed dropwise with 5-chloro-thiophene-2-carbonyl chloride (7.61 g, 42 mmol). Ice-cooling is removed and the mixture is stirred at room temperature for 3 h and then concentrated under reduced pressure. The residue is admixed with water and the solid is filtered off. The crude product is purified by flash chromatography over silica gel (dichloromethane).
후처리
- temperatureIce-cooling
- customis removed
- concentrationconcentrated under reduced pressure
- filtrationthe solid is filtered off
- customThe crude product is purified by flash chromatography over silica gel (dichloromethane)
출처 및 근거
- ORD 기록
- ord-c02ce5a6e4d64658935876d0d60677c1
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08822458B2
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