Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → N-Cyanoacetylethylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Carbamic acid, ethyl ester | HCID 5641 | — |
| 반응물 | Cyanoacetic acid | HCID 9740 | — |
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-Cyanoacetylethylcarbamate | HCID 23112 | 67% |
반응 단계
2-cyanoacetic acid (85 g, 1 mol) and ethyl aminoformate (89 g, 1 mol) were added to toluene (500 mL). To the mixture was slowly added phosphorus oxychloride (45 mL, 0.5 mol), and then added DMF (5 mL). The reaction was conducted at 70° C. for 2 h. After cooling, water (500 mL) was added to the reaction solution to quench phosphorus oxychloride. The reaction is filtered by suction. The filtered cake was washed with ethyl ether and dried to produce a white solid (104 g) in a yield of 67%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822465B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-710c1d615b944b7f9adc6d68cc7a8ce0 |
| 출처 메모 | uspto-grants-2014_09 |