HCID 178419031, 화합물 → HCID 178418735, 화합물

HRID 6854

반응식

HRID 6854 반응식
C([O:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]([NH2:18])=[NH:17])[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>CCO.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]([NH2:18])=[NH:17])[CH:12]=[CH:13][CH:14]=1

참가 물질

4

반응물 1

HCID 178419031HCID 178419031, 화합물

생성물 1

HCID 178418735HCID 178418735, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of N-(3-benzyloxy-phenyl)guanidine (5.0 g, 20.6 mmol) in EtOH (150 mL) was added palladium on carbon (10%, wet, 50% water, 0.5 g)). The mixture was stirred under hydrogen atmosphere overnight. The reaction was filtered through a plug of celite and the filtrate concentrated in vacuo with toluene azeotroping to affored the desired material (2.83 g, 91%). 1H-NMR (MeOH-d4) δ 6.4–7 (m, 4H)

후처리

  1. filtrationThe reaction was filtered through a plug of celite
  2. concentrationthe filtrate concentrated in vacuo with toluene azeotroping

출처 및 근거

ORD 기록
ord-1c2f6a5a2ec34decaf8e5a51310a14b6
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084159B2

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