Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 2-Bromo-1-(4-pyrimidin-2-ylpiperazin-1-yl)ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Bromoacetyl bromide | HCID 61147 | — |
| 반응물 | 1-(2-Pyrimidinyl)piperazine | HCID 88747 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Bromo-1-(4-pyrimidin-2-ylpiperazin-1-yl)ethanone | HCID 63679846 | 0.1% |
반응 단계
20.2 g bromacetylbromide was dropped to 16.5 g 1-pyrimidin-2-yl-piperazin and 10.2 g triethylamine in 250 mL THF. The reaction was stirred over night at RT and evaporated. The residue was extracted with DCM and water. The organic layer was evaporated and the residue was crystallized with petrolether and then purified by chromatography on silica gel (DCM/MeOH:95/5) to yield 36 mg of the desired compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822464B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-f971d6ac5dfa4b12a4f4c5f44ffe44c2 |
| 출처 메모 | uspto-grants-2014_09 |