Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1,3-Propanedione, 1,3-bis(4-fluorophenyl)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 4'-Fluoroacetophenone | HCID 9828 | — |
| 반응물 | Methyl 4-fluorobenzoate | HCID 67878 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1,3-Propanedione, 1,3-bis(4-fluorophenyl)- | HCID 73896 | — |
반응 단계
9.27 g KOtBu was added to 109 mg 18-Krone-6 and 5 mL 4-fluoracetophenone in 150 mL THF. After 30 min at RT 10.7 g 4-fluoro-benzoic acid methyl ester was added and stirred for 3 h at RT. The reaction was decomposed with water and filtered, the filtrate was concentrated and the residue was purified by chromatography on silica gel (cyclohexane/EE: 98:2). The solvent was removed and 3.9 g of the desired compound was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822464B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-70cfdcee53bf4b3191c40dab3dfbd6eb |
| 출처 메모 | uspto-grants-2014_09 |