Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1-Cyclohexyl-3-(4-fluoro-phenyl)-propane-1,3-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Cyclohexyl methyl ketone | HCID 13207 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Methyl 4-fluorobenzoate | HCID 67878 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-Cyclohexyl-3-(4-fluoro-phenyl)-propane-1,3-dione | HCID 86762668 | — |
반응 단계
0.88 g 60% sodiumhydrid was added 1-cyclohexyl-ethanone in 60 mL THF and stirred for 30 min. Then, 3.25 g 4-fluoro-benzoic acid methyl ester and 200 mg 18-Krone-6 was added to the reaction. The reaction was refluxed 2 h and stirred over night at RT. The reaction was added to 100 mL 1N HCl and extracted with diethylether. The organic layer was concentrated and the residue was purified by chromatography on silica gel and 3 g of the desired compound was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822464B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-b343e2f0437e49488452de340c3fca77 |
| 출처 메모 | uspto-grants-2014_09 |