Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → tert-butyl 2-(2-bromo-4-((3-chloro-4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-Chloro-4-fluorobenzenesulphonyl chloride | HCID 145222 | — |
| 반응물 | t-Butyl 2-(2-bromo-4-((methylamino)methyl)phenoxy)acetate | HCID 66868764 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | tert-butyl 2-(2-bromo-4-((3-chloro-4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)acetate | HCID 67527857 | 59% |
반응 단계
To a solution of t-butyl 2-(2-bromo-4-((methylamino)methyl)phenoxy)acetate (2) (68.8 g, 0.21 mol, 1 eq) in DCM (500 mL) was added triethylamine (42 g, 0.42 mol, 2 eq) and 3-chloro-4-fluorobenzene-1-sulfonyl chloride (47.8 g, 0.21 mol. 1 eq, Aldrich, Milwaukee, Wis., USA). After the mixture was stirred for 2 h at room temperature, DCM was evaporate. Crude product was recrystallized from ethanol to yield tert-butyl 2-(2-bromo-4-((3-chloro-4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)acetate (10) (64 g, 59%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822467B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-fbe159645fc842e3ada662ef177bc857 |
| 출처 메모 | uspto-grants-2014_09 |