4-Fluoro-3-nitrobenzoic acid → 3-Amino-4-fluorobenzoic acid

HRID 6866

반응식

HRID 6866 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[F:13])[C:7]([OH:9])=[O:8])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[F:13])[C:7]([OH:9])=[O:8]

참가 물질

4

반응물 1

HCID 679874-Fluoro-3-nitrobenzoic acid

생성물 1

HCID 753963-Amino-4-fluorobenzoic acid

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 3-nitro-4-fluorobenzoic acid (1.85 g, 10.0 mmol) in MeOH (10 mL) and 5% Pd/C (100 mg) was stirred under an atmosphere of hydrogen and for 6 h. The catalyst was removed by filtration, washed with methanol and the volatiles were removed in vacuo to give compound 8A, 3-amino-4-fluorobenzoic acid, as a light yellow solid (1.50 g, 9.67 mmol, 97%).

후처리

  1. customThe catalyst was removed by filtration
  2. washwashed with methanol
  3. customthe volatiles were removed in vacuo

출처 및 근거

ORD 기록
ord-67fc0467b9744c9cae8a4d6ce0d4b91d
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084160B2

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