Potassium borohydride → [2-(Pyridin-2-ylamino)thiazol-5-yl]methanol
반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]1[S:9][C:10]([CH:13]=[O:14])=[CH:11][N:12]=1.[BH4-].[K+]>C(O)C.CN(C=O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]1[S:9][C:10]([CH2:13][OH:14])=[CH:11][N:12]=1참가 물질
5
실험 절차
To a solution of 2-(pyridin-2-ylamino)thiazole-5-carbaldehyde (410 mg, 2 mmol) in ethanol (15 mL) and DMF (5 mL) was added potassium borohydride (120 mg). The resulting mixture was stirred at RT for 1 h, quenched with 10% sulfuric acid solution and concentrated in vacuo. The residue was extracted with methanol and the methanol solution was concentrated. The crude material was diluted with water, filtered and the solid was washed with water and dried in vacuo to provide compound 9A, [2-(pyridin-2-ylamino)thiazol-5-yl]methanol (385 mg, 93%) as a solid. LC/MS; (M+H)+=208
후처리
- customquenched with 10% sulfuric acid solution
- concentrationconcentrated in vacuo
- extractionThe residue was extracted with methanol
- concentrationthe methanol solution was concentrated
- additionThe crude material was diluted with water
- filtrationfiltered
- washthe solid was washed with water
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-f887d35ea77b46e1a21c1bb7e91e381a
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07084160B2
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