3-(methylthio)-6-nitro-1-phenyl-1H-indazole → 3-(methylthio)-1-phenyl-1H-indazol-6-amine

HRID 68677노트

반응식

HRID 68677 반응식
[CH3:1][S:2][C:3]1[C:11]2[C:6](=[CH:7][C:8]([N+:12]([O-])=O)=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:4]=1>C(OCC)(=O)C.[C].[Pd]>[CH3:1][S:2][C:3]1[C:11]2[C:6](=[CH:7][C:8]([NH2:12])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:4]=1

참가 물질

4

반응물 1

HCID 674475223-(methylthio)-6-nitro-1-phenyl-1H-indazole

생성물 1

HCID 498399773-(methylthio)-1-phenyl-1H-indazol-6-amine

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8857Ethyl Acetate용매

실험 절차

A 100-mL round-bottom flask was purged, flushed and maintained with a hydrogen atmosphere, then, was added a solution of 3-(methylthio)-6-nitro-1-phenyl-1H-indazole (3.5 g, 12.28 mmol, 1.00 equiv) in ethyl acetate (30 mL), Palladium carbon (2.2 g), bubbled with H2 (gas). The resulting solution was stirred for 48 min at room temperature. The solids were filtered out. The resulting mixture was concentrated under vacuum to yield 3-(methylthio)-1-phenyl-1H-indazol-6-amine as brown oil. MS: 256 (MH+)

후처리

  1. customA 100-mL round-bottom flask was purged
  2. customflushed
  3. temperaturemaintained with a hydrogen atmosphere
  4. custombubbled with H2 (gas)
  5. filtrationThe solids were filtered out
  6. concentrationThe resulting mixture was concentrated under vacuum

출처 및 근거

ORD 기록
ord-6674f5b0ea9d4893ac7410c13786772c
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822447B2

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