Hydrogen Peroxide → HCID 136386276, 화합물

HRID 68699

반응식

HRID 68699 반응식
[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][C:8](B(O)O)=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:4]=1)[CH3:2].[OH:21]O>C(OCC)(=O)C>[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][C:8]([OH:21])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:4]=1)[CH3:2]

참가 물질

4

반응물 2

HCID 784Hydrogen PeroxideHCID 674485553-ethyl-1-phenyl-1H-indazol-6-ylboronic acid

생성물 1

HCID 136386276HCID 136386276, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
0 °C

실험 절차

Into a 50-mL round-bottom flask, was placed a solution of 3-ethyl-1-phenyl-1H-indazol-6-ylboronic acid (1.4 g, 5.26 mmol, 1.00 equiv) in ethyl acetate (10 mL). To the resulting mixture was then added H2O2 (2 mL) dropwise with stirring at 0° C. The resulting solution was stirred for 2 h at 0° C. in a water/ice bath. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:10) to yield 3-ethyl-1-phenyl-1H-indazol-6-ol as a white solid. MS: 239 (MH+).

후처리

  1. customInto a 50-mL round-bottom flask, was placed
  2. concentrationThe resulting mixture was concentrated under vacuum

출처 및 근거

ORD 기록
ord-c48c154d24654ca6bf097e1aea3e9b1d
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822447B2

연결된 노트

불러오는 중…