2-Bromopropanedial → 2-(4-Methylpyridin-2-ylamino)-thiazole-5-carbaldehyde

HRID 6874

반응식

HRID 6874 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]([NH2:11])=[S:10])[CH:3]=1.Br[CH:13]([CH:16]=O)[CH:14]=[O:15].C([O-])(=O)C.[Na+]>C(O)(=O)C.O>[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[S:10][C:13]([CH:14]=[O:15])=[CH:16][N:11]=2)[CH:3]=1

참가 물질

6

반응물 3

HCID 749452-BromopropanedialHCID 517045Sodium AcetateHCID 2760059(4-Methyl-pyridin-2-yl)-thiourea

생성물 1

HCID 220190842-(4-Methylpyridin-2-ylamino)-thiazole-5-carbaldehyde수율 80%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of (4-methylpyridin-2-yl)-thiourea (334 mg, 2 mmol), 2-bromomalonaldehyde (302 mg, 2 mmol) and sodium acetate (250 mg, 3.0 mmol) in acetic acid (5 mL) was stirred at 100° C. for 3 h. The mixture was cooled to RT and diluted with water and the precipitate formed was collected, washed with water and dried to afford 2-(4-methylpyridin-2-ylamino)-thiazole-5-carbaldehyde (350 mg, 80%). MS m/z 220 (M+H)+.

후처리

  1. temperatureThe mixture was cooled to RT
  2. customthe precipitate formed
  3. customwas collected
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-2e1d32d3e8fb4e439de64c8c1b26c148
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084160B2

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