2-Fluoro-5-methylpyridine → N-Cyclopropyl-N-[1-(5-methyl-pyridin-2-yl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide
반응식
[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[C:5](=[O:17])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[O:16][CH:15]=[N:14][CH:13]=3)=[CH:8][CH:7]=2)[CH2:3][CH2:2]1.F[C:25]1[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][N:26]=1>>[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][N:21]([C:25]3[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][N:26]=3)[CH2:20][CH2:19]2)[C:5](=[O:17])[C:6]2[CH:7]=[CH:8][C:9]([C:12]3[O:16][CH:15]=[N:14][CH:13]=3)=[CH:10][CH:11]=2)[CH2:3][CH2:2]1참가 물질
3
실험 절차
The title compound is prepared from N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide and 2-fluoro-5-methyl-pyridine following a procedure analogous to that described in Example 19. LC (method 5): tR=1.49 min; Mass spectrum (ESI+): m/z=403 [M+H]+.
출처 및 근거
- ORD 기록
- ord-a97616f85f8545e9bc3e7eff90f64414
- 출처 데이터셋
- uspto-grants-2014_09