N-(1-Cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide → N-Cyclopropyl-4-oxazol-5-yl-N-{1-[3-(tetrahydro-pyran-4-ylmethyl)-[1,2,4]oxadiazol-5-yl]-piperidin-4-yl}-benzamide
반응식
[C:1]([N:3]1[CH2:8][CH2:7][CH:6]([N:9]([CH:23]2[CH2:25][CH2:24]2)[C:10](=[O:22])[C:11]2[CH:16]=[CH:15][C:14]([C:17]3[O:21][CH:20]=[N:19][CH:18]=3)=[CH:13][CH:12]=2)[CH2:5][CH2:4]1)#[N:2].[OH:26][NH:27][C:28](=N)[CH2:29][CH:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[CH:23]1([N:9]([CH:6]2[CH2:5][CH2:4][N:3]([C:1]3[O:26][N:27]=[C:28]([CH2:29][CH:30]4[CH2:35][CH2:34][O:33][CH2:32][CH2:31]4)[N:2]=3)[CH2:8][CH2:7]2)[C:10](=[O:22])[C:11]2[CH:12]=[CH:13][C:14]([C:17]3[O:21][CH:20]=[N:19][CH:18]=3)=[CH:15][CH:16]=2)[CH2:25][CH2:24]1참가 물질
3
실험 절차
The title compound is prepared from N-(1-cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide and N-hydroxy-2-(tetrahydro-pyran-4-yl)-acetamidine following a procedure analogous to that described in Example 1. LC (method 1): tR=1.13 min; Mass spectrum (ESI+): m/z=478 [M+H]+.
출처 및 근거
- ORD 기록
- ord-69f9ea0f35154fcd98c3efac4d793be8
- 출처 데이터셋
- uspto-grants-2014_09