2-Chloro-5-trifluoromethyl-(1,3,4)thiadiazole → HCID 68290357, 화합물

HRID 68882

반응식

HRID 68882 반응식
Cl.[CH:2]1([N:5]([CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[C:6](=[O:18])[C:7]2[CH:12]=[CH:11][C:10]([C:13]3[O:17][CH:16]=[N:15][CH:14]=3)=[CH:9][CH:8]=2)[CH2:4][CH2:3]1.Cl[C:26]1[S:27][C:28]([C:31]([F:34])([F:33])[F:32])=[N:29][N:30]=1>CN1CCCC1=O>[CH:2]1([N:5]([CH:19]2[CH2:24][CH2:23][N:22]([C:26]3[S:27][C:28]([C:31]([F:34])([F:33])[F:32])=[N:29][N:30]=3)[CH2:21][CH2:20]2)[C:6](=[O:18])[C:7]2[CH:8]=[CH:9][C:10]([C:13]3[O:17][CH:16]=[N:15][CH:14]=3)=[CH:11][CH:12]=2)[CH2:4][CH2:3]1

참가 물질

4

반응물 2

HCID 132467892-Chloro-5-trifluoromethyl-(1,3,4)thiadiazoleHCID 68289930N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride

생성물 1

HCID 68290357HCID 68290357, 화합물

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

The title compound is prepared from N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride and 2-chloro-5-trifluoromethyl-[1,3,4]thiadiazole following a procedure analogous to that described in Example 19 using N-methylpyrrolidinone as solvent. LC (method 17): tR=1.42 min; Mass spectrum (ESI+): m/z=464 [M+H]+.

출처 및 근거

ORD 기록
ord-4fcb7184acb047febee59c50c9a3a4cb
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822471B2

연결된 노트

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