Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 68883생성일: 2026년 10월 25일
N-methyl-2-pyrrolidone → N-Cyclopropyl-N-[1-(5-cyclopropyl-pyrimidin-2-yl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide
https://huagongshe.com/reaction/68883
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 반응물 | 2-((1,1-Dimethylethyl)imino)-N,N-diethylhexahydro-1,3-dimethyl-2lambda5-1,3,2-diazaphosphorin-2-amine | HCID 3513851 | — |
| 반응물 | 2-Chloro-5-cyclopropylpyrimidine | HCID 46864087 | — |
| 반응물 | N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride | HCID 68289930 | — |
| 생성물 | N-Cyclopropyl-N-[1-(5-cyclopropyl-pyrimidin-2-yl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide | HCID 68290561 | — |
반응 단계
A mixture of N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride (35 mg), 2-chloro-5-cyclopropyl-pyrimidine (46 mg), and 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine (82 mg) in N-methylpyrrolidinone (1.5 mol) is stirred at 70° C. overnight. The crude product is purified by preparative HPLC to give the title compound. LC (method 18): tR=1.41 min; Mass spectrum (ESI+): m/z=430 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08822471B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
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| ORD ID | ord-9e651429f62d4195bb16b465012fff3f |
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| 출처 메모 | uspto-grants-2014_09 |
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