Acetonitrile → 4-Amino-1-(5-cyano-2-pyridyl)-4-methylpiperidine

반응식

[CH2:1]([O:2][C:3](=[O:4])[NH:10][C:11]1([CH3:25])[CH2:12][CH2:13][N:14]([c:17]2[n:18][cH:19][c:20]([C:23]#[N:24])[cH:21][cH:22]2)[CH2:15][CH2:16]1)[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:26]1.[CH3:27][Si:28]([I:29])([CH3:30])[CH3:31].[CH3:32][C:33]#[N:34]>>[NH2:10][C:11]1([CH3:25])[CH2:12][CH2:13][N:14]([c:17]2[n:18][cH:19][c:20]([C:23]#[N:24])[cH:21][cH:22]2)[CH2:15][CH2:16]1

참가 물질

반응물 3

HCID 6342Acetonitrile

HCID 85247Trimethylsilyl iodide

HCID 66756595(5'-Cyano-4-methyl-3,4,5,6-tetrahydro-2H-(1,2')bipyridinyl-4-yl)-carbamic Acid Benzyl Ester

생성물 1

HCID 129691214-Amino-1-(5-cyano-2-pyridyl)-4-methylpiperidine

출처 및 근거

ORD 기록: ord-537601ad0ecd4edc86670b34b7acd242
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

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