4-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)benzoic acid → HCID 71293483, 화합물

반응식

[CH:1]1([NH:4][C@@H:5]2[CH2:10][CH2:9][N:8]([C:11]3[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][N:12]=3)[CH2:7][C@@H:6]2[F:21])[CH2:3][CH2:2]1.[CH3:22][C:23]1[N:27]([C:28]2[CH:36]=[CH:35][C:31]([C:32](O)=[O:33])=[CH:30][CH:29]=2)[N:26]=[N:25][N:24]=1>>[CH:1]1([N:4]([C@@H:5]2[CH2:10][CH2:9][N:8]([C:11]3[CH:16]=[CH:15][C:14]([C:17]([F:18])([F:20])[F:19])=[CH:13][N:12]=3)[CH2:7][C@@H:6]2[F:21])[C:32](=[O:33])[C:31]2[CH:35]=[CH:36][C:28]([N:27]3[C:23]([CH3:22])=[N:24][N:25]=[N:26]3)=[CH:29][CH:30]=2)[CH2:2][CH2:3]1

참가 물질

반응물 2

HCID 31552494-(5-methyl-1H-1,2,3,4-tetrazol-1-yl)benzoic acid

HCID 68289590HCID 68289590, 화합물

생성물 1

HCID 71293483HCID 71293483, 화합물

실험 절차

The title compound is prepared from (3S,4R)-cyclopropyl-(3-fluoro-5′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)-amine and 4-(5-methyl-tetrazol-1-yl)-benzoic acid following a procedure analogous to that described in Example 107. LC (method 19): tR=4.26 min; Mass spectrum (ESI+): m/z=490 [M+H]+.

출처 및 근거

ORD 기록: ord-65267916d9764f33925e8719497ead1c
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08822471B2

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