2-Amino-4,5,6,7-tetrahydrobenzothiazole → 2-methylsulfanyl-4-oxo-5,6,7,8-tetrahydro-4H-9-thia-1,4a-diaza-fluorene-3-carboxylic acid

HRID 68936

반응식

HRID 68936 반응식
[S:1]1[C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:4]=2[N:3]=[C:2]1[NH2:10].[CH2:11]([S:13][C:14](SCC)=[C:15]1[C:20](=O)[O:19]C(C)(C)[O:17][C:16]1=[O:24])C>C(O)C>[CH3:11][S:13][C:14]1[N:10]=[C:2]2[N:3]([C:20](=[O:19])[C:15]=1[C:16]([OH:24])=[O:17])[C:4]1[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=1[S:1]2

참가 물질

4

반응물 2

HCID 180462-Amino-4,5,6,7-tetrahydrobenzothiazoleHCID 136798125-[Bis(ethylsulfanyl)methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

생성물 1

HCID 671171072-methylsulfanyl-4-oxo-5,6,7,8-tetrahydro-4H-9-thia-1,4a-diaza-fluorene-3-carboxylic acid수율 46.8%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
87.5 °C

실험 절차

The suspension of 4,5,6,7-tetrahydro-benzothiazol-2-yl-amine (8 gm, 0.0519 mol) and 5-(bis-ethylsulfanyl-methylene)-2,2-dimethyl-[1,3]dioxane-4,6-dione (14.2 gm, 0.0572 mol) in ethanol (60 ml) was heated at 85-90° C. for 10 hours. Reaction mixture was cooled to room temperature and filtered. The solid, thus obtained, was washed with ethanol (20 ml) followed by with diethyl ether (50 ml) and suck dried to give 7.2 gm of title compound as a solid.

후처리

  1. customReaction mixture
  2. temperaturewas cooled to room temperature
  3. filtrationfiltered
  4. customThe solid, thus obtained
  5. washwas washed with ethanol (20 ml)
  6. customsuck dried

출처 및 근거

ORD 기록
ord-1d8e0f44e55846caa74804a84a556536
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822484B2

연결된 노트

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