Ammonia methanol → 6-{3-[(2-aminoethyl)-N-(pyridin-4-ylmethyl)amino]propoxy}-1-methyl-1H-quinolin-2-one

HRID 69029노트

반응식

HRID 69029 반응식
C(OC(=O)C)C.Cl.C(OC(=O)[NH:14][CH2:15][CH2:16][N:17]([CH2:25][CH2:26][CH2:27][O:28][C:29]1[CH:30]=[C:31]2[C:36](=[CH:37][CH:38]=1)[N:35]([CH3:39])[C:34](=[O:40])[CH:33]=[CH:32]2)[CH2:18][C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1)(C)(C)C.CO.N>C(OCC)(=O)C>[NH2:14][CH2:15][CH2:16][N:17]([CH2:25][CH2:26][CH2:27][O:28][C:29]1[CH:30]=[C:31]2[C:36](=[CH:37][CH:38]=1)[N:35]([CH3:39])[C:34](=[O:40])[CH:33]=[CH:32]2)[CH2:18][C:19]1[CH:20]=[CH:21][N:22]=[CH:23][CH:24]=1

참가 물질

5

반응물 3

HCID 21705897Ammonia methanolHCID 21866389Hydrogen chloride-ethyl acetateHCID 86762698(2-{[3-(1-Methyl-2-oxo-1,2-dihydro-quinolin-6-yloxy)-propyl]-pyridin-4-ylmethyl-amino}-ethyl)-carbamic acid tert-butyl ester

생성물 1

HCID 867626976-{3-[(2-aminoethyl)-N-(pyridin-4-ylmethyl)amino]propoxy}-1-methyl-1H-quinolin-2-one수율 79.6%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A 4N-hydrogen chloride ethyl acetate solution (0.22 ml) was added to an ethyl acetate solution (3 ml) of (2-{[3-(1-Methyl-2-oxo-1,2-dihydro-quinolin-6-yloxy)-propyl]-pyridin-4-ylmethyl-amino}-ethyl)-carbamic acid tert-butyl ester (137 mg), and the mixture was stirred at room temperature overnight. 5N-Ammonia methanol solution (1 ml) was added to the reaction mixture, and the generated insoluble matter was separated by filtration. The filtrate was condensed under reduced pressure to give the title compound (85.7 mg) as an colorless oil.

후처리

  1. customthe generated insoluble matter was separated by filtration
  2. customcondensed under reduced pressure

출처 및 근거

ORD 기록
ord-dec831807d8147fb959588ecd8ccd13c
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822453B2

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