Iodine → HCID 178516694, 화합물

HRID 69043

반응식

HRID 69043 반응식
C(=O)([O-])[O-].[K+].[K+].[OH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[CH:10][CH:9]=1.[I:18]I.C(=O)([O-])O.[Na+].S([O-])([O-])=O.[Na+].[Na+]>O.CN(C=O)C>[I:18][C:9]1[CH:10]=[N:11][C:12]2[C:17]([C:8]=1[OH:7])=[CH:16][CH:15]=[CH:14][CH:13]=2

참가 물질

8

반응물 5

HCID 807IodineHCID 11430Potassium CarbonateHCID 24437Sodium SulfiteHCID 516892Sodium BicarbonateHCID 178516385quinolin-4-ol

생성물 1

HCID 178516694HCID 178516694, 화합물수율 96.4%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

Potassium carbonate (5.2 g) was added to a DMF solution (50 ml) of 4-hydroxy quinoline (5.0 g) and the mixture was stirred. Iodine (9.6 g) was added to the mixture, followed by stirring at room temperature for 3 hours. A saturated sodium hydrogencarbonate aqueous solution (73 ml) of 25% sodium sulfite, and water (50 ml) were added to the reaction mixture. The mixture was stirred and the precipitated insoluble matter was separated. The filtrate was washed with water and dried to give the title compound (9.0 g) as a white powder.

후처리

  1. stirringby stirring at room temperature for 3 hours
  2. stirringThe mixture was stirred
  3. customthe precipitated insoluble matter was separated
  4. washThe filtrate was washed with water
  5. customdried

출처 및 근거

ORD 기록
ord-95f11b102de64b3bbe148233931cfbd0
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822453B2

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