Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 691생성일: 2026년 10월 23일
1-Bromo-4-(methylsulphonyl)benzene → tert-butyl (2R)-2-methyl-4-(4-methylsulfonylphenyl)piperazine-1-carboxylate
https://huagongshe.com/ko/reaction/691
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Bromo-4-(methylsulphonyl)benzene | HCID 77014 | — |
| 반응물 | tert-Butyl (2R)-2-methylpiperazine-1-carboxylate | HCID 10262201 | — |
| 시약 | Potassium tert-butoxide | HCID 23665647 | — |
| 촉매 | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| 촉매 | Bis(tri-tert-butylphosphine)palladium(0) | HCID 2734558 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | tert-butyl (2R)-2-methyl-4-(4-methylsulfonylphenyl)piperazine-1-carboxylate | HCID 133499578 | 0% |
반응 단계
13-May-09 10:32:28 +0100 1-bromo-4-(methylsulfonyl)benzene (515 mg, 2.13 mmol), (R)-tert-butyl 2-methylpiperazine-1-carboxylate (426 mg, 2.13 mmol) and BIS(TRI-T- BUTYLPHOSPHINE)PALLADIUM(0) (54.3 mg, 0.11 mmol) and potassium 2-methylpropan-2-olate (352 mg, 2.98 mmol) were suspended in dioxane (10 mL) and heated to 90°C for 3 hours. LC-MS shows starting material. Reaction abandoned.
출처 및 근거
| 출처 데이터셋 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-8f20cf3b966d4cdd9e1178539b8e969e |
|---|
| 출처 메모 | 750 AstraZeneca ELN dataset |
|---|
