Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → (6-Chloroimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | [2-(6-Chloro-3-pyridazinyl)-2-azavinyl]dimethylamine | HCID 6802247 | — |
| 반응물 | 2-Bromo-1-(quinolin-6-yl)ethan-1-one | HCID 71699692 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | (6-Chloroimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone | HCID 86630275 | — |
반응 단계
A mixture of N′-(6-chloro-pyridazin-3-yl)-N,N-dimethyl-formamidine (Stage 1.6, 2 g, 10.8 mmol), 2-bromo-1-quinolin-6-yl-ethanone (Stage 1.3, 3.36 g, 10.8 mmol) and triethylamine (1.1 g, 10.8 mmol) was stirred under reflux for 90 min. The reaction was allowed to cool and water (100 mL) was then added. The resulting red precipitate was filtered off to afford the title compound as a red solid (tR 1.2 min(conditions 1), MH+=309).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822468B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-a3c3b3b4a60845de82fab6907bdca040 |
| 출처 메모 | uspto-grants-2014_09 |