Triethylamine → (6-Chloroimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone

HRID 69150

반응식

HRID 69150 반응식
[Cl:1][C:2]1[N:7]=[N:6][C:5]([N:8]=[CH:9]N(C)C)=[CH:4][CH:3]=1.Br[CH2:14][C:15]([C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[N:23]=[CH:22][CH:21]=[CH:20]2)=[O:16].C(N(CC)CC)C>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:14]([C:15]([C:17]3[CH:18]=[C:19]4[C:24](=[CH:25][CH:26]=3)[N:23]=[CH:22][CH:21]=[CH:20]4)=[O:16])=[CH:9][N:8]=2)[N:7]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 6802247[2-(6-Chloro-3-pyridazinyl)-2-azavinyl]dimethylamineHCID 716996922-Bromo-1-(quinolin-6-yl)ethan-1-one

생성물 1

HCID 86630275(6-Chloroimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of N′-(6-chloro-pyridazin-3-yl)-N,N-dimethyl-formamidine (Stage 1.6, 2 g, 10.8 mmol), 2-bromo-1-quinolin-6-yl-ethanone (Stage 1.3, 3.36 g, 10.8 mmol) and triethylamine (1.1 g, 10.8 mmol) was stirred under reflux for 90 min. The reaction was allowed to cool and water (100 mL) was then added. The resulting red precipitate was filtered off to afford the title compound as a red solid (tR 1.2 min(conditions 1), MH+=309).

후처리

  1. temperatureunder reflux for 90 min
  2. temperatureto cool
  3. filtrationThe resulting red precipitate was filtered off

출처 및 근거

ORD 기록
ord-a3c3b3b4a60845de82fab6907bdca040
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822468B2

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