참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-Aminopiperidine-2,6-dione hydrochloride | HCID 134548 | — |
| 반응물 | Methyl 2-(bromomethyl)-4-nitrobenzoate | HCID 15088701 | — |
| 생성물 | 6-Methyl-2-nitrobenzoic acid | HCID 16097 | — |
| 생성물 | N-bromobutanimide | HCID 67184 | — |
| 생성물 | Methyl 2-(bromomethyl)-4-nitrobenzoate | HCID 15088701 | — |
반응 단계
This compound can be prepared according to the methods described in U.S. Pat. Nos. 6,281,230 and 5,635,517, the entireties of which are incorporated herein by reference. For example, the compound can be prepared through catalytic hydrogenation of 3-(4-nitro-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione. 3-(4-Nitro-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione can be obtained by allowing 2,6-dioxopiperidin-3-ammonium chloride to react with methyl 2-bromomethyl-4-nitrobenzoate in dimethylformamide in the presence of triethylamine. The methyl 2-bromomethyl-4-nitrobenzoate in turn is obtained from the corresponding methyl ester of nitro-ortho-toluic acid by conventional bromination with N-bromosuccinimide under the influence of light.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08822499B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-2aa42e2d16a7451995b8d9779e985718 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
