2-(2-Chloroethyl)-4-methoxybenzoyl chloride → 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-6-methoxy-3,4-dihydro-2H-isoquinolin-1-one

HRID 69413노트

반응식

HRID 69413 반응식
Cl[CH2:2][CH2:3][C:4]1[CH:12]=[C:11]([O:13][CH3:14])[CH:10]=[CH:9][C:5]=1[C:6](Cl)=[O:7].[NH2:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[CH2:26][CH2:25][C@@H:24]([N:27]([CH3:29])[CH3:28])[CH2:23]2)=[C:18]([F:30])[CH:17]=1>>[CH3:28][N:27]([CH3:29])[C@@H:24]1[CH2:25][CH2:26][N:22]([C:19]2[CH:20]=[CH:21][C:16]([N:15]3[CH2:2][CH2:3][C:4]4[C:5](=[CH:9][CH:10]=[C:11]([O:13][CH3:14])[CH:12]=4)[C:6]3=[O:7])=[CH:17][C:18]=2[F:30])[CH2:23]1

참가 물질

3

반응물 2

HCID 124011862-(2-Chloroethyl)-4-methoxybenzoyl chlorideHCID 68977761[(R)-1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]dimethylamine

생성물 1

HCID 689879542-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-6-methoxy-3,4-dihydro-2H-isoquinolin-1-one

실험 절차

2-(2-Chloroethyl)-4-methoxybenzoyl chloride was reacted with [(R)-1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]dimethylamine by method A. The product with the molecular weight of 383.47 (C22H26FN3O2) was obtained in this way; MS (ESI): 384 (M+H+).

후처리

  1. customThe product with the molecular weight of 383.47 (C22H26FN3O2) was obtained in this way

출처 및 근거

ORD 기록
ord-f86f2582a82b41dd8e806ccb3599797e
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822495B2

반응 노트

불러오는 중…