p-Toluenesulfonic acid → HCID 68988088, 화합물

HRID 69419노트

반응식

HRID 69419 반응식
[CH2:1]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[C:12](=[O:16])[N:11]([C:17]1[CH:22]=[CH:21][C:20]([N:23]3[CH2:31][CH2:30][C:25]4(OCC[O:26]4)[CH2:24]3)=[CH:19][CH:18]=1)[CH2:10][CH2:9]2)[CH2:2][CH2:3][CH3:4].C1(C)C=CC(S(O)(=O)=O)=CC=1>CC(C)=O>[CH2:1]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[C:12](=[O:16])[N:11]([C:17]1[CH:22]=[CH:21][C:20]([N:23]3[CH2:31][CH2:30][C:25](=[O:26])[CH2:24]3)=[CH:19][CH:18]=1)[CH2:10][CH2:9]2)[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 2

HCID 6101p-Toluenesulfonic acidHCID 689920606-butoxy-2-[4-(1,4-dioxa-7-azaspiro[4.4]non-7-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one

생성물 1

HCID 68988088HCID 68988088, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 6-butoxy-2-[4-(1,4-dioxa-7-azaspiro[4.4]non-7-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one (1.40 g), p-toluenesulfonic acid (57 mg) and acetone (40 mL) was boiled under reflux for 12 hours and then concentrated. The residue was partitioned between sodium carbonate solution and ethyl acetate. The organic phase was dried and concentrated. The product with the molecular weight of 378.48 (C23H26N2O3) was obtained in this way; MS (ESI): 379 (M+H+).

후처리

  1. temperatureunder reflux for 12 hours
  2. concentrationconcentrated
  3. customThe residue was partitioned between sodium carbonate solution and ethyl acetate
  4. customThe organic phase was dried
  5. concentrationconcentrated
  6. customThe product with the molecular weight of 378.48 (C23H26N2O3) was obtained in this way

출처 및 근거

ORD 기록
ord-6dfa129263f14983beed32c30c97c363
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822495B2

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