Butanal → 1,1-Di-(5-fluoroindol-3-yl)-butane

반응식

[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[CH:11](=O)[CH2:12][CH2:13][CH3:14]>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]([C:5]1[C:4]2[C:8](=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=2)[NH:7][CH:6]=1)[CH2:12][CH2:13][CH3:14]

참가 물질

반응물 2

HCID 261Butanal

HCID 678615-Fluoroindole

생성물 1

HCID 220193091,1-Di-(5-fluoroindol-3-yl)-butane수율 45%

실험 절차

This was prepared in the same way as described in example 2/2 starting from 5-fluoroindole and butyraldehyde. The reaction, however, was heated under reflux for 24 hours. The end product was isolated and purified by chromatography on an SiO2 column using a hexane:ethyl ether gradient ranging from 7:3 to 4:6 as the eluent. Yield 45%.

후처리

customThis was prepared in the same way
customThe reaction
temperaturehowever, was heated
temperatureunder reflux for 24 hours
customThe end product was isolated
custompurified by chromatography on an SiO2 column

출처 및 근거

ORD 기록: ord-40492c21a69f46b88fd0fa2d519864ca
출처 데이터셋: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07084166B2

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