2-(2-Chloroethyl)-4-methoxybenzoyl chloride → (S)-7-[4-(6-methoxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-phenyl]-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester

HRID 69437

반응식

HRID 69437 반응식
Cl[CH2:2][CH2:3][C:4]1[CH:12]=[C:11]([O:13][CH3:14])[CH:10]=[CH:9][C:5]=1[C:6](Cl)=[O:7].[C:15]([O:19][C:20]([N:22]1[CH2:26][CH2:25][C@:24]2([CH2:30][CH2:29][N:28]([C:31]3[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][CH:32]=3)[CH2:27]2)[CH2:23]1)=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20]([N:22]1[CH2:26][CH2:25][C@:24]2([CH2:30][CH2:29][N:28]([C:31]3[CH:36]=[CH:35][C:34]([N:37]4[CH2:2][CH2:3][C:4]5[C:5](=[CH:9][CH:10]=[C:11]([O:13][CH3:14])[CH:12]=5)[C:6]4=[O:7])=[CH:33][CH:32]=3)[CH2:27]2)[CH2:23]1)=[O:21])([CH3:18])([CH3:16])[CH3:17]

참가 물질

3

반응물 2

HCID 124011862-(2-Chloroethyl)-4-methoxybenzoyl chlorideHCID 68994472(S)-7-(4-amino-phenyl)-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester

생성물 1

HCID 68990290(S)-7-[4-(6-methoxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-phenyl]-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester

실험 절차

According to Method A, 2-(2-chloroethyl)-4-methoxy-benzoyl chloride was reacted with (S)-7-(4-amino-phenyl)-2,7-diaza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester. In this way the product was obtained with molecular weight 477.61 (C28H35N3O4); MS (ESI): 478 (M+H+).

후처리

  1. customIn this way the product was obtained with molecular weight 477.61 (C28H35N3O4)

출처 및 근거

ORD 기록
ord-bdcf3269df004ea8a7f86e53f38608ea
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822495B2

연결된 노트

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