Isobutylene oxide → 6-Cyclopropylmethoxy-2-{3-fluoro-4-[7-(2-hydroxy-2-methyl-propyl)-2,7-diaza-spiro[4.4]non-2-yl]-phenyl}-2H-isoquinolin-1-one
반응식
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][CH:15]=2)[C:12](=[O:16])[N:11]([C:17]2[CH:22]=[CH:21][C:20]([N:23]4[CH2:27][CH2:26][C:25]5([CH2:31][CH2:30][NH:29][CH2:28]5)[CH2:24]4)=[C:19]([F:32])[CH:18]=2)[CH:10]=[CH:9]3)[CH2:3][CH2:2]1.[CH3:33][C:34]1([CH3:37])[CH2:36][O:35]1>>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][CH:15]=2)[C:12](=[O:16])[N:11]([C:17]2[CH:22]=[CH:21][C:20]([N:23]4[CH2:27][CH2:26][C:25]5([CH2:31][CH2:30][N:29]([CH2:33][C:34]([OH:35])([CH3:37])[CH3:36])[CH2:28]5)[CH2:24]4)=[C:19]([F:32])[CH:18]=2)[CH:10]=[CH:9]3)[CH2:3][CH2:2]1참가 물질
3
실험 절차
According to Method U, 6-cyclopropylmethoxy-2-[4-(2,7-diaza-spiro[4.4]non-2-yl)-3-fluorophenyl]-2H-isoquinolin-1-one was reacted with 2,2-dimethyl-oxirane. In this way the product was obtained with molecular weight 505.64 (C30H36FN3O3); MS (ESI): 506 (M+H+).
후처리
- customIn this way the product was obtained with molecular weight 505.64 (C30H36FN3O3)