2-Bromothiazole → 2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluorophenyl)-6-(thiazol-2-yloxy)-2H-isoquinolin-1-one
반응식
[N:1]1([C@@H:6]2[CH2:10][CH2:9][N:8]([C:11]3[CH:16]=[CH:15][C:14]([N:17]4[CH:26]=[CH:25][C:24]5[C:19](=[CH:20][CH:21]=[C:22]([OH:27])[CH:23]=5)[C:18]4=[O:28])=[CH:13][C:12]=3[F:29])[CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.Br[C:31]1[S:32][CH:33]=[CH:34][N:35]=1>>[N:1]1([C@@H:6]2[CH2:10][CH2:9][N:8]([C:11]3[CH:16]=[CH:15][C:14]([N:17]4[CH:26]=[CH:25][C:24]5[C:19](=[CH:20][CH:21]=[C:22]([O:27][C:31]6[S:32][CH:33]=[CH:34][N:35]=6)[CH:23]=5)[C:18]4=[O:28])=[CH:13][C:12]=3[F:29])[CH2:7]2)[CH2:2][CH2:3][CH2:4][CH2:5]1참가 물질
3
실험 절차
According to Method AB, 2-((R)-4-[1,3′]bipyrrolidinyl-1′-yl-3-fluorophenyl)-6-hydroxy-2H-isoquinolin-1-one was reacted with 2-bromothiazole. In this way the product was obtained with molecular weight 476.58 (C26H25FN4O2S); MS (ESI): 477 (M+H+).
후처리
- customIn this way the product was obtained with molecular weight 476.58 (C26H25FN4O2S)