1-Benzyl-4-piperidone → 1-Benzyl-4-methylpiperidin-4-ol

HRID 69484노트

반응식

HRID 69484 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](=[O:14])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:15][Li]>>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([CH3:15])([OH:14])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 192201-Benzyl-4-piperidoneHCID 178418348HCID 178418348, 화합물

생성물 1

HCID 108459131-Benzyl-4-methylpiperidin-4-ol

실험 절차

1-Benzyl-piperidin-4-one was reacted with methyllithium according to Method AI and the 1-benzyl-4-methyl-piperidin-4-ol obtained was hydrogenated in debenzylating conditions according to Method AH. In this way the product was obtained with molecular weight 115.1 (C6H13NO); MS (ESI): 116 (M+H+).

출처 및 근거

ORD 기록
ord-95707ea0463f418f87866a7d892da643
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822495B2

반응 노트

불러오는 중…