참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Metaperiodic acid | HCID 65185 | — |
| 반응물 | 2-hydroxy-5-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one | HCID 68988098 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Oxolane--water (1/1) | HCID 21881883 | — |
| 생성물 | 3-Hydroxy-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-isochroman-1-one | HCID 68991857 | — |
반응 단계
A solution of periodic acid in water (0.5 M; 5.2 mL) was added at 0° C. to a solution of 2-hydroxy-5-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one (581 mg) in water/THF 1:1 (12 mL) and the solution was stirred at 0° C. for 1 h. After adding water it was extracted with ether, dried over magnesium sulfate and concentrated. The residue was purified by preparative HPLC. In this way the product was obtained with molecular weight 264.28 (C14H16O5); MS (ESI): 265 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08822495B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-b450f26fa40345c3a2ee6e4962b671cd |
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| 출처 메모 | uspto-grants-2014_09 |
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