HCID 178418203, 화합물 → N-[5-[[3-cyano-7-(oxetan-3-ylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-cyclopropyl-4-fluorophenyl]acetamide

참여 물질

역할	이름	HCID	투입량
반응물	HCID 178418203	HCID 178418203	—
반응물	HCID 178418222	HCID 178418222	—
시약	Cesium carbonate	HCID 10796	—
촉매	Bis(dibenzylideneacetone)palladium	HCID 9811564	—
촉매	Di-tert-butyl(2',4',6'-tris(propan-2-yl)-(1,1'-biphenyl)-2-yl)phosphane	HCID 11618717	—
용매	1,4-Dioxane	HCID 31275	—
생성물	N-[5-[[3-cyano-7-(oxetan-3-ylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-cyclopropyl-4-fluorophenyl]acetamide	HCID 72164290	11.85%

반응 조건

온도	130 °C

반응 단계

The mixture of N-(5-amino-2-cyclopropyl-4-fluorophenyl)acetamide (54.2 mg, 0.26 mmol), 5-chloro-7-(oxetan-3-ylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile (50.0 mg, 0.20 mmol), cesium carbonate (196 mg, 0.60 mmol), Pd2(dba)3 (18.34 mg, 0.02 mmol) and di-tert-butyl(2',4',6'-triisopropylbiphenyl-2-yl)phosphine (17.01 mg, 0.04 mmol) sealed with microwave vial was degassed and refilled with argon 3 times. Then the degassed dioxane (4 mL) was added. The resulting solution was heated at 130°C for 30 mins in microwave. After removed all the solvents, the crude residue was purified by chromatography (100% EtOAc to 3% MeOH in EtOAc). N-(5-(3-cyano-7-(oxetan-3-ylamino)pyrazolo[1,5-a]pyrimidin-5-ylamino)-2-cyclopropyl-4-fluorophenyl)acetamide (10.00 mg, 11.85 %) was obtained.

출처 및 근거

출처 데이터셋	750 AstraZeneca ELN dataset
ORD ID	ord-f2ae1a21bc9f45a9af6696711f426a7c
출처 메모	750 AstraZeneca ELN dataset