1-[2-(3-Methyl-2-nitrophenoxy)-ethyl]-pyrrolidine → 1h-Indole,7-[2-(1-pyrrolidinyl)ethoxy]-

HRID 6950

반응식

HRID 6950 반응식
[CH3:1]N(C)CCOC1C=CC=C(C)C=1[N+]([O-])=O.[CH3:17][C:18]1[C:19]([N+:32]([O-])=O)=[C:20]([CH:29]=[CH:30][CH:31]=1)[O:21][CH2:22][CH2:23][N:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1.N1C2C(=CC=CC=2OCCN(C)C)C=C1>>[N:24]1([CH2:23][CH2:22][O:21][C:20]2[CH:29]=[CH:30][CH:31]=[C:18]3[C:19]=2[NH:32][CH:1]=[CH:17]3)[CH2:28][CH2:27][CH2:26][CH2:25]1

참가 물질

4

반응물 3

HCID 116012601-[2-(3-Methyl-2-nitrophenoxy)-ethyl]-pyrrolidineHCID 22019395[2-(1H-indol-7-yloxy)-ethyl]-dimethyl-amineHCID 22019404Dimethyl-[2-(3-methyl-2-nitro-phenoxy)-ethyl]-amine

생성물 1

HCID 115648771h-Indole,7-[2-(1-pyrrolidinyl)ethoxy]-

실험 절차

The following compound was prepared in a similar fashion, starting with dimethyl-[2-(3-methyl-2-nitro-phenoxy)-ethyl]-amine rather than 1-[2-(3-methyl-2-nitrophenoxy)-ethyl]-pyrrolidine: [2-(1H-indol-7-yloxy)-ethyl]-dimethyl-amine (69%), MS: 205 (M+H)+

후처리

  1. customThe following compound was prepared in a similar fashion

출처 및 근거

ORD 기록
ord-d630b16d159d461ab24d52bd054d2105
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084169B2

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