(S)-1-(tetrahydrofuran-2-yl)methyl methanesulfonate → 6-[(S)-1-(Tetrahydrofuran-2-yl)methoxy]isochroman-1-one

반응식

[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[O:7][CH2:6][CH2:5]2.[O:13]1[CH2:17][CH2:16][CH2:15][C@H:14]1[CH2:18]OS(C)(=O)=O>>[O:13]1[CH2:17][CH2:16][CH2:15][C@H:14]1[CH2:18][O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[O:7][CH2:6][CH2:5]2

참가 물질

반응물 2

HCID 18649743(S)-1-(tetrahydrofuran-2-yl)methyl methanesulfonate

HCID 552751836-Hydroxyisochroman-1-one

생성물 1

HCID 666799246-[(S)-1-(Tetrahydrofuran-2-yl)methoxy]isochroman-1-one

실험 절차

6-Hydroxy-isochroman-1-one was reacted with Methanesulfonic acid (S)-1-(tetrahydro-furan-2-yl)methyl ester by method K1. The product with the molecular weight of 248.28 (C14H28FN3O3) was obtained in this way; MS (ESI): 249 (M+H+).

후처리

customThe product with the molecular weight of 248.28 (C14H28FN3O3) was obtained in this way

출처 및 근거

ORD 기록: ord-9f1b5cd813824eb0918c0a20c665674d
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08822495B2

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