Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(Bromomethyl)oxane → 2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-(tetrahydro-pyran-4-ylmethoxy)-2H-isoquinolin-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(Bromomethyl)oxane | HCID 2773286 | — |
| 반응물 | 2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-hydroxy-2H-isoquinolin-1-one | HCID 68989350 | — |
| 생성물 | 2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-(tetrahydro-pyran-4-ylmethoxy)-2H-isoquinolin-1-one | HCID 57916900 | — |
반응 단계
2-((R)-4-[1,3′]Bipyrrolidinyl-1′-yl-3-fluoro-phenyl)-6-hydroxy-2H-isoquinolin-1-one was reacted with 4-Bromomethyl-tetrahydro-pyran by method K. The product with the molecular weight of 491.61 (C29H34FN3O3) was obtained in this way; MS (ESI): 492 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822495B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-4b83a62b467644a9817b9dcc490d030f |
| 출처 메모 | uspto-grants-2014_09 |