HCID 17948959, 화합물 → 4-(2,2-Difluoroethyl)pyrrolidin-2-one
반응식
[F:1][C:2]([F:10])=[CH:3][CH:4]1[CH2:8][NH:7][C:6](=[O:9])[CH2:5]1>[Pd].CO>[F:1][CH:2]([F:10])[CH2:3][CH:4]1[CH2:8][NH:7][C:6](=[O:9])[CH2:5]1참가 물질
4
실험 절차
A solution of 4-(2,2-difluoroethenyl)pyrrolidin-2-one a1 (2.8 g, 18.77 mmol, 1 eq) and palladium on charcoal (10% Wt, 300 mg) in methanol (500 ml) is stirred overnight under an hydrogen atmosphere (40 psi) at room temperature. The reaction mixtured is filtered over celite and the solvent is removed under reduced pressure to afford 4-(2,2-difluoroethyl)pyrrolidin-2-one a11 which can be used in the next step without any further purification.
후처리
- customThe reaction
- filtrationmixtured is filtered over celite
- customthe solvent is removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-f18b7aa74a03440a9e73c6b6bacb5116
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08822508B2
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