Methanol → HCID 178501206, 화합물

HRID 69573노트

반응식

HRID 69573 반응식
[NH2:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([C:8]([OH:10])=[O:9])[CH2:4][CH2:3]1.O=S(Cl)Cl.[CH3:15]O>>[NH2:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([C:8]([O:10][CH3:15])=[O:9])[CH2:4][CH2:3]1

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 178511566HCID 178511566, 화합물

생성물 1

HCID 178501206HCID 178501206, 화합물

실험 절차

A suspension of cis-4-aminocyclohexanecarboxylic acid (5.0 g, 34.9 mmol) in methanol (50 mL) was stirred at room temperature and SOCl2 (7.1 mL, 98.4 mmol) was added dropwise over 20 minutes, causing the solid to dissolve. The solution was stirred overnight and the methanol was then removed under reduced pressure. The residual solid was triturated with diethyl ether and air-dried and the title compound obtained as an off-white powder (6.0 g).

후처리

  1. dissolutionto dissolve
  2. stirringThe solution was stirred overnight
  3. customthe methanol was then removed under reduced pressure
  4. customThe residual solid was triturated with diethyl ether
  5. customair-dried

출처 및 근거

ORD 기록
ord-19a1bec3ede94b669c9aac4e46b2f15b
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822507B2

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