Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 69578생성일: 2026년 10월 23일
Methyl 6-chloro-5-nitronicotinate → (S)-Methyl 6-(2-(methoxycarbonyl)pyrrolidin-1-yl)-5-nitronicotinate
https://huagongshe.com/ko/reaction/69578
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl 6-chloro-5-nitronicotinate | HCID 346961 | — |
| 반응물 | Methyl L-prolinate | HCID 853477 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (S)-Methyl 6-(2-(methoxycarbonyl)pyrrolidin-1-yl)-5-nitronicotinate | HCID 58324504 | 94% |
반응 단계
(S)-Methyl pyrrolidine-2-carboxylate (6.56 g, 50.8 mmol) was added to methyl 6-chloro-5-nitronicotinate (5.00 g, 23.1 mmol) and the reaction mixture was stirred at 90° C. for 10 min (exothermic reaction). It as cooled to room temperature, diluted with EtOAc (10 mL) and purified using flash column chromatography on silica gel (20-30% EtOAc in hexanes) to afford the title compound as a yellow oil (6.70 g, 94%). [M+H] calc'd for C13H15N3O6, 310; found, 310.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08822470B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
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| ORD ID | ord-c4624cc82689407eb29e51e1a7ca835d |
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| 출처 메모 | uspto-grants-2014_09 |
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