Dichloromethane → 3-chloro-N-[(4,4-difluoropyrrolidin-2-yl)methyl]aniline

HRID 697243노트

반응식

HRID 697243 반응식
[C:8]([O:9][C:10](=[O:11])[N:15]1[CH:16]([CH2:22][NH:23][c:24]2[cH:25][c:26]([Cl:30])[cH:27][cH:28][cH:29]2)[CH2:17][C:18]([F:20])([F:21])[CH2:19]1)([CH3:12])([CH3:13])[CH3:14].[Cl:31][CH2:32][Cl:33].[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7]>>[NH:15]1[CH:16]([CH2:22][NH:23][c:24]2[cH:25][c:26]([Cl:30])[cH:27][cH:28][cH:29]2)[CH2:17][C:18]([F:20])([F:21])[CH2:19]1

참가 물질

4

반응물 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 66774597Tert-butyl 2-[(3-chloroanilino)methyl]-4,4-difluoropyrrolidine-1-carboxylate

생성물 1

HCID 667736663-chloro-N-[(4,4-difluoropyrrolidin-2-yl)methyl]aniline

출처 및 근거

ORD 기록
ord-fef74ce19c6a4b5c90591c5a1ff7e9ba
출처 데이터셋
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

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