참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Piperazine | HCID 4837 | — |
| 반응물 | 4-fluoro-N-methylbenzene-1-sulfonamide | HCID 2440054 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-methyl-4-(piperazin-1-yl)benzene-1-sulfonamide | HCID 23288834 | 87% |
반응 단계
4-fluoro-N-methylbenzenesulfonamide (189 mg, 0.999 mmol) and piperazine (430 mg, 4.99 mmol) were combined and the reaction mixture was stirred at 120° C. for 2 h. It was diluted with water (5 mL) and stirred until a fine suspension resulted. The precipitate was filtered, washed with water (5×3 mL) and dried in vacuum to afford N-methyl-4-(piperazin-1-yl)benzenesulfonamide (222 mg, 0.869 mmol, 87% yield) as a white solid. ESI-MS: m/z 256 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08822470B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-8ffc550874ab49deaf3f150f3c66c61d |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
