Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,3-Difluoro-2-nitrobenzene → tert-Butyl 1-(3-fluoro-2-nitrophenyl)piperidine-4-ylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,3-Difluoro-2-nitrobenzene | HCID 87922 | — |
| 반응물 | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | tert-Butyl 1-(3-fluoro-2-nitrophenyl)piperidine-4-ylcarbamate | HCID 53255566 | 93% |
반응 단계
Method 1 was followed using 1 eq each of 2,6-difluoronitrobenzene, 4-(N-Boc-amino) piperidine, and TEA in EtOH yielding tert-butyl 1-(3-fluoro-2-nitrophenyl)piperidin-4-ylcarbamate (93%). LCMS (m/z): 340.1 (MH+); LC Rt=3.30 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822497B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-59927f3e78434f798cfb8d58841466f5 |
| 출처 메모 | uspto-grants-2014_09 |