Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,4-Difluoronitrobenzene → Tert-butyl 1-(5-fluoro-2-nitrophenyl)-piperidin-4-ylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,4-Difluoronitrobenzene | HCID 67967 | — |
| 반응물 | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| 생성물 | Tert-butyl 1-(5-fluoro-2-nitrophenyl)-piperidin-4-ylcarbamate | HCID 69044868 | 93% |
반응 단계
Method 1 was followed using 1 eq each of 1,3-difluoro-4-nitrobenzene, 4-(N-Boc-amino) piperidine, and TEA yielding tert-butyl 1-(5-fluoro-2-nitrophenyl)-piperidin-4-ylcarbamate (93%). LCMS (m/z): 340.1 (MH+); LC Rt=3.24 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822497B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-b0546e3539b24065b65fdd9cab43f212 |
| 출처 메모 | uspto-grants-2014_09 |