4-Chloro-3-nitroanisole → Tert-butyl 1-(4-methoxy-2-nitrophenyl)piperidin-3-ylcarbamate

HRID 69845

반응식

HRID 69845 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11].[C:13]([NH:20][CH:21]1[CH2:26][CH2:25][CH2:24][NH:23][CH2:22]1)([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14]>>[CH3:9][O:8][C:5]1[CH:6]=[CH:7][C:2]([N:23]2[CH2:24][CH2:25][CH2:26][CH:21]([NH:20][C:13](=[O:14])[O:15][C:16]([CH3:18])([CH3:17])[CH3:19])[CH2:22]2)=[C:3]([N+:10]([O-:12])=[O:11])[CH:4]=1

참가 물질

3

반응물 2

HCID 251404-Chloro-3-nitroanisoleHCID 42330413-(Boc-amino)piperidine

생성물 1

HCID 68163072Tert-butyl 1-(4-methoxy-2-nitrophenyl)piperidin-3-ylcarbamate수율 50%

실험 절차

Method 1 was followed using 4-chloro-3-nitroanisole (1.0 eq), 3-(N-Boc-amino) piperidine (1.2 eq), and TEA (2.0 eq) at 60° C. for 72 hours yielding tert-butyl 1-(4-methoxy-2-nitrophenyl)piperidin-3-ylcarbamate (50%). LCMS (m/z): 352.1 (MH+); LC Rt=3.27 min.

후처리

  1. customat 60° C.
  2. customfor 72 hours

출처 및 근거

ORD 기록
ord-07d00c6b401e498681c93624ef3122fd
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822497B2

연결된 노트

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