4-Chloro-3-nitroanisole → HCID 69043384, 화합물

HRID 69847

반응식

HRID 69847 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11].[C:13]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14]>CN1C(=O)CCC1>[CH3:9][O:8][C:5]1[CH:6]=[CH:7][C:2]([N:23]2[CH2:22][CH2:21][N:20]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:25][CH2:24]2)=[C:3]([N+:10]([O-:12])=[O:11])[CH:4]=1

참가 물질

4

반응물 2

HCID 251404-Chloro-3-nitroanisoleHCID 143452tert-Butyl piperazine-1-carboxylate

생성물 1

HCID 69043384HCID 69043384, 화합물수율 50%

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

Method 1 was followed using 4-chloro-3-nitroanisole (1.0 eq), 1-Boc-piperazine (1.2 eq), and TEA (2.0 eq) in NMP at 100° C. for 16 hours yielding tert-butyl 4-(4-methoxy-2-nitro phenyl)piperazine-1-carboxylate (50%). LCMS (m/z): 338.2 (MH+); LC Rt=3.37 min.

후처리

  1. customat 100° C.
  2. customfor 16 hours

출처 및 근거

ORD 기록
ord-7e48c55b25b54539b5ea005c80ce382d
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822497B2

연결된 노트

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