4-Fluoro-3-nitrobenzotrifluoride → Tert-butyl 1-(2-nitro-4-(trifluoromethyl)phenyl)piperidin-4-ylcarbamate

HRID 69854

반응식

HRID 69854 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[C:15]([NH:22][CH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16]>>[N+:12]([C:3]1[CH:4]=[C:5]([C:8]([F:11])([F:10])[F:9])[CH:6]=[CH:7][C:2]=1[N:26]1[CH2:25][CH2:24][CH:23]([NH:22][C:15](=[O:16])[O:17][C:18]([CH3:20])([CH3:19])[CH3:21])[CH2:28][CH2:27]1)([O-:14])=[O:13]

참가 물질

3

반응물 2

HCID 677784-Fluoro-3-nitrobenzotrifluorideHCID 7238334-(N-Boc-amino)piperidine

생성물 1

HCID 60507337Tert-butyl 1-(2-nitro-4-(trifluoromethyl)phenyl)piperidin-4-ylcarbamate수율 99%

실험 절차

Method 1 was followed using 1-fluoro-2-nitro-4-(trifluoromethyl)benzene (1.0 eq), 4-(N-Boc-amino) piperidine (1.2 eq), and TEA (2.0 eq) at 55° C. for 1 hour yielding tert-butyl 1-(2-nitro-4-(trifluoromethyl)phenyl)piperidin-4-ylcarbamate (99%). LCMS (m/z): 390.1 (MH+); LC Rt=3.51 min.

후처리

  1. customat 55° C.
  2. customfor 1 hour

출처 및 근거

ORD 기록
ord-d329cfa233874d5da4ed6b527034578b
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822497B2

연결된 노트

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