Benzene, 2-fluoro-4-methyl-1-nitro- → Tert-butyl 1-(5-methyl-2-nitrophenyl)piperidin-4-ylcarbamate

HRID 69857

반응식

HRID 69857 반응식
F[C:2]1[CH:3]=[C:4]([CH3:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[C:12]([NH:19][CH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13]>>[CH3:11][C:4]1[CH:5]=[CH:6][C:7]([N+:8]([O-:10])=[O:9])=[C:2]([N:23]2[CH2:22][CH2:21][CH:20]([NH:19][C:12](=[O:13])[O:14][C:15]([CH3:17])([CH3:16])[CH3:18])[CH2:25][CH2:24]2)[CH:3]=1

참가 물질

3

반응물 2

HCID 67966Benzene, 2-fluoro-4-methyl-1-nitro-HCID 7238334-(N-Boc-amino)piperidine

생성물 1

HCID 69090317Tert-butyl 1-(5-methyl-2-nitrophenyl)piperidin-4-ylcarbamate수율 97%

실험 절차

Method 1 was followed using 3-fluoro-4-nitrotoluene (1.0 eq), 4-(N-Boc-amino) piperidine (1.2 eq), and TEA (2.0 eq) at 55° C. for 48 hours yielding tert-butyl 1-(5-methyl-2-nitrophenyl)piperidin-4-ylcarbamate (97%). LCMS (m/z): 336.1 (MH+); LC Rt=3.32 min

후처리

  1. customat 55° C.
  2. customfor 48 hours

출처 및 근거

ORD 기록
ord-a7db61b6f3ad431692165270d3381105
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822497B2

연결된 노트

불러오는 중…