1-Fluoro-4-methanesulfonyl-2-nitrobenzene → Tert-butyl 1-(4-(methylsulfonyl)-2-nitrophenyl)piperidin-4-ylcarbamate

HRID 69860

반응식

HRID 69860 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[C:15]([NH:22][CH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16]>>[CH3:11][S:8]([C:5]1[CH:6]=[CH:7][C:2]([N:26]2[CH2:25][CH2:24][CH:23]([NH:22][C:15](=[O:16])[O:17][C:18]([CH3:20])([CH3:19])[CH3:21])[CH2:28][CH2:27]2)=[C:3]([N+:12]([O-:14])=[O:13])[CH:4]=1)(=[O:10])=[O:9]

참가 물질

3

반응물 2

HCID 3131371-Fluoro-4-methanesulfonyl-2-nitrobenzeneHCID 7238334-(N-Boc-amino)piperidine

생성물 1

HCID 69046390Tert-butyl 1-(4-(methylsulfonyl)-2-nitrophenyl)piperidin-4-ylcarbamate

실험 절차

Method 1 was followed using 1-fluoro-4-(methylsulfonyl)-2-nitrobenzene (1.0 eq), 4-(N-Boc-amino) piperidine (1.1 eq), and TEA (2.0 eq) at 55° C. for 24 hours yielding tert-butyl 1-(4-(methylsulfonyl)-2-nitrophenyl)piperidin-4-ylcarbamate. LCMS (m/z): 400.1 (MH+); LC Rt=2.83 min.

후처리

  1. customat 55° C.
  2. customfor 24 hours

출처 및 근거

ORD 기록
ord-75c6b68084494180a3f9a8c59155a8cb
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822497B2

연결된 노트

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